AI methods are increasingly shaping pharmaceutical drug discovery. However, their translation to industrial applications remains limited due to their reliance on public datasets, lacking scale and diversity of proprietary pharmaceutical data. Federated learning (FL) offers a promising approach to integrate private data into privacy-preserving, collaborative model training across data silos. This federated data access complicates important data-centric tasks such as estimating dataset diversity, performing informed data splits, and understanding the structure of the combined chemical space. To address this gap, we investigate how well federated clustering methods can disentangle and represent distributed molecular data. We benchmark three approaches, Federated kMeans (Fed-kMeans), Federated Principal Component Analysis combined with Fed-kMeans (Fed-PCA+Fed-kMeans), and Federated Locality-Sensitive Hashing (Fed-LSH), against their centralized counterparts on eight diverse molecular datasets. Our evaluation utilizes both, standard mathematical and a chemistry-informed evaluation metrics, SF-ICF, that we introduce in this work. The large-scale benchmarking combined with an in-depth explainability analysis shows the importance of incorporating domain knowledge through chemistry-informed metrics, and on-client explainability analyses for federated diversity analysis on molecular data.

Federated learning paradigm to utilize datasets across multiple data providers. In FL, cross-silo data providers often hesitate to share their high-quality dataset unless their data value can be fairly assessed. Shapley value (SV) has been advocated as the standard metric for data valuation in FL due to its desirable properties. However, the computational overhead of SV is prohibitive in practice, as it inherently requires training and evaluating an FL model across an exponential number of dataset combinations. Furthermore, existing solutions fail to achieve high accuracy and efficiency, making practical use of SV still out of reach, because they ignore choosing suitable computation scheme for approximation framework and overlook the property of utility function in FL. We first propose a unified stratified-sampling framework for two widely-used schemes. Then, we analyze and choose the more promising scheme under the FL linear regression assumption. After that, we identify a phenomenon termed key combinations, where only limited dataset combinations have a high-impact on final data value. Building on these insights, we propose a practical approximation algorithm, IPSS, which strategically selects high-impact dataset combinations rather than evaluating all possible combinations, thus substantially reducing time cost with minor approximation error. Furthermore, we conduct extensive evaluations on the FL benchmark datasets to demonstrate that our proposed algorithm outperforms a series of representative baselines in terms of efficiency and effectiveness.

Federated Learning (FL) is an upcoming technology that is increasingly applied in real-world applications. Early applications focused on cross-device scenarios, where many participants with limited resources train machine learning (ML) models together, e.g., in the case of Google's GBoard. Contrarily, cross-silo scenarios have only few participants but with many resources, e.g., in the healthcare domain. Despite such early efforts, FL is still rarely used in practice and best practices are, hence, missing. For new applications, in our case inter-organizational cross-silo applications, overcoming this lack of role models is a significant challenge. In order to ease the use of FL in real-world cross-silo applications, we here propose a scenario-based architecture for the practical use of FL in the context of multiple companies collaborating to improve the quality of their ML models. The architecture emphasizes the collaboration between the participants and the FL server and extends basic interactions with domain-specific features. First, it combines governance with authentication, creating an environment where only trusted participants can join. Second, it offers traceability of governance decisions and tracking of training processes, which are also crucial in a production environment. Beyond presenting the architectural design, we analyze requirements for the real-world use of FL and evaluate the architecture with a scenario-based analysis method.

Combining different data modalities enables deep neural networks to tackle complex tasks more effectively, making multimodal learning increasingly popular. To harness multimodal data closer to end users, it is essential to integrate multimodal learning with privacy-preserving training approaches such as federated learning (FL). However, compared to conventional unimodal learning, multimodal setting requires dedicated encoders for each modality, resulting in larger and more complex models that demand significant resources. This presents a substantial challenge for FL clients operating with limited computational resources and communication bandwidth. To address these challenges, we introduce LW-FedMML, a layer-wise federated multimodal learning approach, which decomposes the training process into multiple steps. Each step focuses on training only a portion of the model, thereby significantly reducing the memory and computational requirements. Moreover, FL clients only need to exchange the trained model portion with the central server, lowering the resulting communication cost. We conduct extensive experiments across various FL scenarios and multimodal learning setups to validate the effectiveness of our proposed method. The results demonstrate that LW-FedMML can compete with conventional end-to-end federated multimodal learning (FedMML) while significantly reducing the resource burden on FL clients. Specifically, LW-FedMML reduces memory usage by up to $2.7\times$, computational operations (FLOPs) by $2.4\times$, and total communication cost by $2.3\times$. We also introduce a progressive training approach called Prog-FedMML. While it offers lesser resource efficiency than LW-FedMML, Prog-FedMML has the potential to surpass the performance of end-to-end FedMML, making it a viable option for scenarios with fewer resource constraints.

This study proposes a framework to enhance privacy in Blockchain-based Internet of Things (BIoT) systems used in the healthcare sector. The framework addresses the challenge of leveraging health data for analytics while protecting patient privacy. To achieve this, the study integrates Differential Privacy (DP) with Federated Learning (FL) to protect sensitive health data collected by IoT nodes. The proposed framework utilizes dynamic personalization and adaptive noise distribution strategies to balance privacy and data utility. Additionally, blockchain technology ensures secure and transparent aggregation and storage of model updates. Experimental results on the SVHN dataset demonstrate that the proposed framework achieves strong privacy guarantees against various attack scenarios while maintaining high accuracy in health analytics tasks. For 15 rounds of federated learning with an epsilon value of 8.0, the model obtains an accuracy of 64.50%. The blockchain integration, utilizing Ethereum, Ganache, Web3.py, and IPFS, exhibits an average transaction latency of around 6 seconds and consistent gas consumption across rounds, validating the practicality and feasibility of the proposed approach.

Federated learning (FL) enables multiple data owners (a.k.a. FL clients) to collaboratively train machine learning models without disclosing sensitive private data. Existing FL research mostly focuses on the monopoly scenario in which a single FL server selects a subset of FL clients to update their local models in each round of training. In practice, there can be multiple FL servers simultaneously trying to select clients from the same pool. In this paper, we propose a first-of-its-kind Fairness-aware Federated Job Scheduling (FairFedJS) approach to bridge this gap. Based on Lyapunov optimization, it ensures fair allocation of high-demand FL client datasets to FL jobs in need of them, by jointly considering the current demand and the job payment bids, in order to prevent prolonged waiting. Extensive experiments comparing FairFedJS against four state-of-the-art approaches on two datasets demonstrate its significant advantages. It outperforms the best baseline by 31.9% and 1.0% on average in terms of scheduling fairness and convergence time, respectively, while achieving comparable test accuracy.

Federated learning (FL) systems face performance challenges in dealing with heterogeneous devices and non-identically distributed data across clients. We propose a dynamic global model aggregation method within Asynchronous Federated Learning (AFL) deployments to address these issues. Our aggregation method scores and adjusts the weighting of client model updates based on their upload frequency to accommodate differences in device capabilities. Additionally, we also immediately provide an updated global model to clients after they upload their local models to reduce idle time and improve training efficiency. We evaluate our approach within an AFL deployment consisting of 10 simulated clients with heterogeneous compute constraints and non-IID data. The simulation results, using the FashionMNIST dataset, demonstrate over 10% and 19% improvement in global model accuracy compared to state-of-the-art methods PAPAYA and FedAsync, respectively. Our dynamic aggregation method allows reliable global model training despite limiting client resources and statistical data heterogeneity. This improves robustness and scalability for real-world FL deployments.

Recent advancements in federated learning (FL) have greatly facilitated the development of decentralized collaborative applications, particularly in the domain of Artificial Intelligence of Things (AIoT). However, a critical aspect missing from the current research landscape is the ability to enable data-driven client models with symbolic reasoning capabilities. Specifically, the inherent heterogeneity of participating client devices poses a significant challenge, as each client exhibits unique logic reasoning properties. Failing to consider these device-specific specifications can result in critical properties being missed in the client predictions, leading to suboptimal performance. In this work, we propose a new training paradigm that leverages temporal logic reasoning to address this issue. Our approach involves enhancing the training process by incorporating mechanically generated logic expressions for each FL client. Additionally, we introduce the concept of aggregation clusters and develop a partitioning algorithm to effectively group clients based on the alignment of their temporal reasoning properties. We evaluate the proposed method on two tasks: a real-world traffic volume prediction task consisting of sensory data from fifteen states and a smart city multi-task prediction utilizing synthetic data. The evaluation results exhibit clear improvements, with performance accuracy improved by up to 54% across all sequential prediction models.

Federated Learning (FL) has emerged as a promising paradigm to train machine learning models collaboratively while preserving data privacy. However, its widespread adoption faces several challenges, including scalability, heterogeneous data and devices, resource constraints, and security concerns. Despite its promise, FL has not been specifically adapted for community domains, primarily due to the wide-ranging differences in data types and context, devices and operational conditions, environmental factors, and stakeholders. In response to these challenges, we present a novel framework for Community-based Federated Learning called CommunityAI. CommunityAI enables participants to be organized into communities based on their shared interests, expertise, or data characteristics. Community participants collectively contribute to training and refining learning models while maintaining data and participant privacy within their respective groups. Within this paper, we discuss the conceptual architecture, system requirements, processes, and future challenges that must be solved. Finally, our goal within this paper is to present our vision regarding enabling a collaborative learning process within various communities.

Blockchain promises to enhance distributed machine learning (ML) approaches such as federated learning (FL) by providing further decentralization, security, immutability, and trust, which are key properties for enabling collaborative intelligence in next-generation applications. Nonetheless, the intrinsic decentralized operation of peer-to-peer (P2P) blockchain nodes leads to an uncharted setting for FL, whereby the concepts of FL round and global model become meaningless, as devices' synchronization is lost without the figure of a central orchestrating server. In this paper, we study the practical implications of outsourcing the orchestration of FL to a democratic network such as in a blockchain. In particular, we focus on the effects that model staleness and inconsistencies, endorsed by blockchains' modus operandi, have on the training procedure held by FL devices asynchronously. Using simulation, we evaluate the blockchained FL operation on the well-known CIFAR-10 dataset and focus on the accuracy and timeliness of the solutions. Our results show the high impact of model inconsistencies on the accuracy of the models (up to a ~35% decrease in prediction accuracy), which underscores the importance of properly designing blockchain systems based on the characteristics of the underlying FL application.